张志荣，博士，毕业于中国台湾长庚大学医学院，曾任长庚大学基础医学院研究所助理教授，长期从事肠道菌研究、益生菌基础研究、外泌体研究及临床转化应用，在自然通讯等期刊发表多篇论文。主持或主要参加国家、省、市各类科研项目。

论文发表:

1. Lai HC, Chang CJ, Yang CH, Hsu YJ, Chen CC, Lin CS, Tsai YH, Huang TT, Ojcius DM, Tsai YH, Lu CC*. Activation of NK cell cytotoxicity by the natural compound 2,3-butanediol. Journal of Leukocyte Biology 2012 Oct;92 (4):807-14.

2. Chang CJ, Chen YY, Lu CC, Lin CS, Martel J, Tsai SH, Ko YF, Huang TT, Ojcius DM, Young JD*, Lai HC*. Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin. Innate Immunity. 2014 Apr; 20(3):301-11.

3. Huang TT, Lai HC, Chen YB, Chen LG, Wu YH, Ko YF, Lu CC, Chang CJ, Wu CY, Martel J, Ojcius DM, Chong KY*, Young JD*. Cis-Resveratrol produces anti-inflammatory effects by inhibiting canonical and non-canonical inflammasomes in macrophage. Innate Immunity. 2014;20:735-50. 

4. Chun-Hung Yang, Hui-Ling Wang, Yi-Sheng Lin, K.P. Shravan Kumar, Hung-Chi Lin, Chih-Jung Chang, Chia-Chen Lu, Tsung-Teng Huang, Jan Martel, David M. Ojcius, Yu-Sun Chang, John D. Young* and Hsin-Chih Lai*. Identification of CD24 as a cancer stem cell marker in human nasopharyngeal carcinoma. Plos one 2014 Jun 23;9(6):e99412 

5. Chia-Chen Lu, Ting Shu Wu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Ju-Hsin Chia, Tsu-Lan Wu, Tsung-Teng Huang, Jan Martel, David Ojcius, John D. Young* and Hsin-Chih Lai*. Direct perforin-dependent killing of mycobacteria by NK cells. Journal of Leukocyte Biology 2014 Dec;96(6):1119-29 

6. Chuan-Sheng Lin#, Chih-Jung Chang#, Chia-Chen Lu, Jan Martel, David M. Ojcius, Yun-Fei Ko, John D.Young*, Hsin-Chih Lai*. Impact of the gut microbiota, prebiotics, and probiotics on human health and disease. Biomedical Journal 2014 Sep-Oct; 37(5):259-68 
7. Chih-Jung Chang, Gut microbiota, Obesity and Traditional Chinese Medicine. Journal of Biomedical & Laboratory Sciences, 2014.

8. Chih-Jung Chang#, Chuan-Sheng Lin#, Chia-Chen Lu, Jan Martel, Yun-Fei Ko, David M. Ojcius, Shun-Fu Tseng, Tsung-Ru Wu, Yi-Yuan Margaret Chen, John D. Young* & Hsin-Chih Lai*. Ganoderma lucidum mycelium modulates the gut microbiota and reduces obesity in mice. Nature Communications. 2015 Jun 23;6:7489

9. Chia-Chen Lu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Jan Martel, David M Ojcius, Yun-Fei Ko, Hsin-Chih Lai*, John D Young*. Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity. Innate Immunity. 2016 Oct;22(7):522-33.

10. Chuan-Sheng Lin, Yu-Huan Tsai, Chih-Jung Chang, Shun-Fu Tseng, Tsung-Ru Wu, Chia-Chen Lu, Ting-Shu Wu, Jang-Jih Lu, Jim-Tong Horng, Jan Martel, David M. Ojcius, Hsin-Chih Lai& John D. Young*. An iron detection system determines bacterial swarming initiation and biofilm formation. Scientific Reports 2016 Nov 15;6:36747. 

11. Chuan-Sheng Lin, Chih-Jung Chang, Jan Martel, David M. Ojcius, Wei-Fan Lai, Chia-Chen Lu, Yun-Fei Ko, John D.Young*, Hsin-Chih Lai. Lipopolysaccharide: friend of foe? Journal of Biomedical & Laboratory Sciences. 2016;28:121

12. Jan Martel, David M. Ojcius, Chih-Jung Chang, Chuan-Sheng Lin, Chia-Chen Lu, Yun-Fei Ko, Shun-Fu Tseng, Hsin-Chih Lai* & John D. Young*. Anti-obesogenic and antidiabetic effects of plants and mushrooms. Nature Review Endocrinology. 2017 Mar;13(3):149-160. 

13. Wei CF, Tsai YH, Tsai SH, Lin CS, Chang CJ, Lu CC, Huang HC, Lai HC. Cross-talk between bacterial two-component systems drives stepwise regulation of flagellar biosynthesis in swarming development. Biochem Biophys Res Commun. 2017 Jul 15;489(1):70-75 

14. Martel J, Ko YF, Ojcius DM, Lu CC, Chang CJ, Lin CS, Lai HC, Young JD. Immunomodulatory Properties of Plants and Mushrooms. Trends Pharmacol Sci. 2017 Nov;38(11):967-981 

15. Schachter J, Martel J, Lin CS, Chang CJ, Wu TR, Lu CC, Ko YF, Lai HC, Ojcius DM, Young JD. Effects of obesity on depression: A role for inflammation and the gut microbiota. Brain Behav Immun. 2017 Sep 6. pii: S0889-1591(17)30415-4

16. Chang CJ, Lu CC, Lin CS, Martel J, Ko YF, Ojcius DM, Wu TR, Tsai YH, Yeh TS, Lu JJ, Lai HC, Young JD. Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. Int J Obes (Lond). 2018 Feb;42(2):231-243

17. Lai HC, Chang CJ, Lin CS, Wu TR, Hsu YJ, Wu TS, Lu JJ, Martel J, Ojcius DM, Ku CL, Young JD, Lu CC. NK Cell-Derived IFN-γ Protects against Nontuberculous Mycobacterial Lung Infection. J Immunol. 2018 Sep 1;201(5):1478-1490. 

18. Wu TR#, Lin CS#, Chang CJ#, Lin TL, Martel J, Ko YF, Ojcius DM, Lu CC, Young JD, Lai HC. Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis. Gut. 2019 Feb;68(2):248-262 

19. Tsai YL, Lin TL, Chang CJ, Wu TR, Lai WF, Lu CC, Lai HC. Probiotics, prebiotics and amelioration of diseases. J Biomed Sci. 2019 Jan 4;26(1):3 

20. Martel J, Ojcius DM, Ko YF, Chang CJ, Young JD. Antiaging effects of bioactive molecules isolated from plants and fungi. Med Res Rev. 2019 Sep;39(5):1515-1552 

21. Chih-Jung Chang, Tzu-Lung Lin, Yu-Ling Tsai, Tsung-Ru Wu, Wei-Fan Lai, Chia-Chen Lu and Hsin-Chih Lai. Next generation probiotics in disease amelioration. J Food Drug Anal. 2019 Jul;27(3):615-622.

22. Yu-Ling Tsai, Wen-Chiuan Tsai, ZhuQing, Chih-Jung Chang. Dichotomous effects of microbial membrane vesicles on the regulation of immunity. Medicine in Microecology, 2020 March, Corresponding author)

23. Chang CJ, Chen CB, Hung SI, Ji C, Chung WH. Pharmacogenetic Testing for Prevention of Severe Cutaneous Adverse Drug Reactions. Front Pharmacol 2020 Jul 2;11:969

24. Hsin-Chih Lai, Tzu-Lung Lin, Ting-Wen Chen, Yu-Lun Kuo, Chih-Jung Chang  Tsung-Ru Wu, Ching-Chung Shu, Ying-Huang Tsai, Simon Swift, Chia-Chen Lu. Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide. Gut. 2022;71(2):309-321

25. Yu-Chieh Weng, Wei-Ting Chen, Jung-Chieh Lee, Yung-Ning Huang, Chih-Kai Yang, Hui-Shan Hsieh, Chih-Jung Chang, Yang-Bor Lu. Intestinal fatty acid-binding protein is a biomarker for diagnosis of biliary tract infection. JGH Open. 2021;5:1160

26. Chang CJ, Wang H, Zhang J, Zou Y, Zhang Y, Chen J, Chen CB, Chung WH, Ji C. Distinct proteomic profiling of plasma extracellular vesicles from moderate-to-severe atopic dermatitis patients. Clin Cosmet Investig Dermatol. 2021;14:1033

27. Chih-Jung Chang, Jing Zhang, Yu-Ling Tsai, Chun-Bing Chen, Chun-Wei Lu, Yu-Ping Huo, Huey-Ming Liou, Chao Ji *, Wen-Hung Chung *. Compositional Features of Distinct Microbiota Base on Serum Extracellular Vesicle Metagenomics Analysis in Moderate to Severe Psoriasis Patients. Cells. 2021;10:2349 

28. Tsai-Yeh, Chiang, Yu-Ru Yang, Ming-Ying Zhuo, Feng Yang, Ying-Fei Zhang, Chia-Hsiang Fu, Ta-Jen Lee, Wen-Hung Chung, Liang Chen, Chih-Jung Chang. Microbiome profiling of nasal extracellular vesicles in patients with allergic rhinitis. World Allergy Organization Journal 2022; 15:100674 

29. Wang CW, Chi MH, Tsai TF, Yu KH, Kao HW, Chen HC, Chen CB, Lu CW, Chen WT, Chang YC, Chang CJ, Chang YT, Jan Wu YJ, Chang CJ, Huang YH, Ng CY, Huang PW, Lin YJ, Hui RC, Chung WH. Implementation of NUDT15 genotyping to prevent Azathioprine-induced leukopenia for patients with autoimmune disorders in Chinese population. Clin Pharmacol Ther 2022 Jul 22. doi: 10.1002/cpt.2716. 

30. Lu CW, Pang JS, Ko YS, Chang CJ, Wang CW, Chen WT, Chen CB, Hui RC, Hung SI, Lu LY, Lu KL, Wang CL, Wu CE, Hsu PC, Fang YF, Li SH, Ko HW, Tseng LC, Shih FY, Chen MJ, Chung WH. Zinc deficiency associated with cutaneous toxicities induced by epidermal growth factor receptor tyrosine kinase inhibitor therapy in patients with lung adenocarcinoma. J Eur Acad Dermatol Venereol. 2022 Nov 10. doi: 10.1111/jdv.18703 

31.Wang CW, Lin WC, Chen WT, Chen CB, Lu CW, Hou HH, Hui RC, Wu J, Chang CJ, Chang YC, Chung WH; Taiwan Severe Cutaneous Adverse Reaction Consortium. Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population. Front Pharmacol. 2022 Nov 25;13:954596 

32.Haifeng Hong, Changhui Lin, Min Fang, Juntian Liu, Hung-Chih Hsu, Chih-Jung Chang, Haibing Wang. Proteomic analysis of exosomal proteins associated with bone healing speed in a rat tibial fracture model. Biomed Chromatogr 2024 Feb 27:e5846 

33.Chih-Jung Chang, Yung-Ning Huang, Yang-Bor Lu, Yi Zhang, Ping-Hua Wu, Jian-Shan Huang, Wei Yang, Tung-Ying Chiang, Hui-Shan Hsieh, Wen-Hung Chung, Yu-Chieh Weng. Proteomic analysis of serum extracellular vesicles from biliary tract infection patients to identify novel biomarkers. Scientific Reports. 2024 Mar 8;14(1):5707. doi: 10.1038/s41598-024-56036-y.

专利申请:

美国：

Ø US9757409B2_Method to prepare Ganoderma lucidum polysaccharides possessing insulin-sensitizing properties and applications thereof

Ø US9758595B2_Method to prepare Ganoderma lucidum polysaccharides possessing anti-obesity properties and uses thereofMethod to prepare Ganoderma lucidum polysaccharides possessing protective activities on fatty liver disease

Ø US9763990_Method to prepare Ganoderma lucidum polysaccharides possessing protective activities on fatty liver diseaseMethod to prepare Hirsutella sinensis polysaccharides possessing insulin-sensitizing properties and applications thereof

Ø US9828442_Method to prepare Hirsutella sinensis polysaccharides possessing insulin-sensitizing properties and applications thereofMethod to reduce body weight, fat accumulation and adipocyte size using Parabacteroides goldsteinii

Ø US10086019B1Method to reduce insulin resistance and improve glucose tolerance using Parabacteroides goldsteinii

Ø US10111915B1_Method to treat fatty liver disease using Parabacteroides goldsteinii

Ø US20160361348A1_Method to prepare hirsutella sinensis polysaccharides possessing anti-obesity properties and uses thereof

Ø US20160361370A1_Method to prepare Hirsutella sinensis polysaccharides possessing protective activities on fatty liver disease

大陆：

Ø CN106188321B_灵芝多糖体作为抑制肥胖的用途及其制备方法

Ø CN106236769A_中国被毛孢多糖体用于促进胰岛素敏感性的用途及其制备方法

Ø CN106236770A_灵芝多糖体用于促进胰岛素敏感性的用途及其制备方法

Ø CN106389459B_灵芝多糖体用于抑制脂肪肝形成的用途及其制备方法

Ø CN109419814B_戈氏副拟杆菌用于抑制脂肪肝疾病的用途

Ø CN109419815A_戈氏副拟杆菌用于制备治疗肥胖的药物的用途

Ø CN109419817B_一种戈氏副拟杆菌用于制备降低高脂饮食后胰岛

Ø CN201510585035_中国被毛孢多糖体用于抑制肥胖的用途及其制备方法

Ø CN201510585202_中国被毛孢多糖体用于治疗脂肪肝疾病的用途及其制备方法

台灣：

Ø 靈芝多醣體用於抑制脂肪肝形成之用途及其製備方法

Ø 靈芝多醣體用於促進胰島素敏感性之用途及其製備方法

Ø 靈芝多醣體作為抑制肥胖之用途及其製備方法

Ø 中華被毛孢多醣體用於抑制肥胖之用途及其製備方法

Ø 中華被毛孢多醣體用於治療脂肪肝疾病之用途及其製備方法

Ø 中華被毛孢多醣體用於促進胰島素敏感性之用途及其製備方法

Ø 戈氏副擬桿菌用於抑制肥胖之用途

Ø 戈氏副擬桿菌用於抑制脂肪肝疾病之用途

Ø 戈氏副擬桿菌用於降低胰島素抗性及提升葡萄糖耐受性之用途

Ø 環狀酪氨酸-纈氨酸及其類似物用於治療氣喘及呼吸道過敏之用途

细胞治疗标准

宏基因组揭开妊娠型糖尿病病人外泌体之菌相变化

细胞及动物评估鱼腥草外囊泡对二型皮肤炎症的效果

利用细胞及动物模式评估鬼针草茎叶外囊泡对特异性皮炎改善效果

哮喘病人呼吸道菌群与生化因子及疾病分型的关系分析

研究多体学揭示中重度过敏疾病患者接受敏原免疫疗法后免疫通路及微生物动态关联